MMP9 inhibition increases erythropoiesis in RPS14-deficient del(5q) MDS models through suppression of TGF-β pathways-Reference-Cited by-同舟云学术

MMP9 inhibition increases erythropoiesis in RPS14-deficient del(5q) MDS models through suppression of TGF-β pathways

Published:2019-09-20 Issue:18 Volume:3 Page:2751-2763
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Youn Minyoung¹,Huang Haigen²,Chen Cheng²,Kam Sharon¹,Wilkes Mark C.¹,Chae Hee-Don¹,Sridhar Kunju J.³,Greenberg Peter L.³,Glader Bertil¹,Narla Anupama¹,Lin Shuo²,Sakamoto Kathleen M.¹

Affiliation:

1. Department of Pediatrics, Stanford University School of Medicine, Stanford, CA;

2. Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA; and

3. Stanford University Cancer Center, Stanford, CA

Abstract

Key Points MMP9 inhibition improves erythropoiesis in RPS14-deficient del(5q) MDS models. Increased MMP9 expression in RPS14-deficient cells activates TGF-β signaling, resulting in defective erythroid developments.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/18/2751/1223301/advancesadv2019000537.pdf

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5. Identification of RPS14 as a 5q- syndrome gene by RNA interference screen;Ebert;Nature,2008

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