CD56 as a marker of an ILC1-like population with NK cell properties that is functionally impaired in AML

Author:

Salomé Bérengère12ORCID,Gomez-Cadena Alejandra13,Loyon Romain1,Suffiotti Madeleine134,Salvestrini Valentina5,Wyss Tania134ORCID,Vanoni Giulia13,Ruan Dan Fu2,Rossi Marianna6,Tozzo Alessandra7,Tentorio Paolo8ORCID,Bruni Elena89,Riether Carsten10ORCID,Jacobsen Eva-Maria11,Jandus Peter12,Conrad Curdin1314ORCID,Hoenig Manfred11ORCID,Schulz Ansgar11,Michaud Katarzyna15ORCID,Della Porta Matteo Giovanni616,Salvatore Silvia7,Ho Ping-Chih13,Gfeller David134,Ochsenbein Adrian10,Mavilio Domenico89ORCID,Curti Antonio17,Marcenaro Emanuela18ORCID,Steinle Alexander19ORCID,Horowitz Amir2,Romero Pedro1,Trabanelli Sara13,Jandus Camilla13ORCID

Affiliation:

1. Department of Oncology UNIL CHUV, University of Lausanne, Lausanne, Switzerland;

2. Department of Oncological Sciences, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY;

3. Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland;

4. Swiss Institute of Bioinformatics, Lausanne, Switzerland;

5. Department of Specialistic, Diagnostic and Experimental Medicine, Institute of Hematology “Seràgnoli,” University Bologna, Bologna, Italy;

6. Cancer Center IRCCS Humanitas Research Hospital, Milan, Italy;

7. Pediatric Department, University of Insubria, Varese, Italy;

8. Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research Center, Rozzano-Milan, Italy;

9. Department of Medical Biotechnologies and Translational Medicine, University of Milan, Milan, Italy;

10. Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;

11. Department of Pediatrics, University Medical Center Ulm, Ulm, Germany;

12. Division of Immunology and Allergology, Department of Medicine, University Hospital and Medical Faculty, Geneva, Switzerland;

13. Department of Dermatology, University Hospital CHUV, Lausanne, Switzerland;

14. Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland;

15. University Center of Legal Medicine Lausanne-Geneva, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland;

16. Department of Biomedical Sciences, Humanitas University, Milan, Italy;

17. Institute of Hematology L. e A. Seràgnoli, Department of Hematology and Oncology, Azienda Ospedaliero-Universitaria S. Orsola-Malpighi, Bologna, Italy;

18. Department of Experimental Medicine and Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy; and

19. Institute for Molecular Medicine, Goethe University Frankfurt, Frankfurt, Germany

Abstract

Key Points Human ILC1-like cells kill tumors in a KIR-independent manner. The cytotoxicity of human ILC1-like cells is impaired in AML at diagnosis but is restored in remission.

Publisher

American Society of Hematology

Subject

Hematology

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