Longitudinal plasma proteomics in CAR T–cell therapy patients implicates neutrophils and NETosis in the genesis of CRS

Author:

Flora Christopher1,Olesnavich Mary1ORCID,Zuo Yu2,Sandford Erin1ORCID,Madhukar Rashmi1,Rozwadowski Michelle3ORCID,Sugur Kavya2,Ly Andrew4,Canbaz Ata Alpay5ORCID,Shedeck Audra5,Li Gen6,Geer Marcus J.1ORCID,Yanik Gregory A.3,Ghosh Monalisa1,Frame David G.7,Bonifant Challice L.58ORCID,Jain Tania45ORCID,Knight Jason S.2,Choi Sung Won39ORCID,Tewari Muneesh19101112

Affiliation:

1. 1Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI

2. 2Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI

3. 3Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Michigan, Ann Arbor, MI

4. 4Johns Hopkins University School of Medicine, Baltimore, MD

5. 5Division of Hematological Malignancies and Bone Marrow Transplantation, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD

6. 6Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI

7. 7Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, MI

8. 8Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD

9. 9Rogel Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI

10. 10Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI

11. 11Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI

12. 12VA Ann Arbor Healthcare System, Ann Arbor, MI

Publisher

American Society of Hematology

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