Effect of chronic opioid therapy on pain and survival in a humanized mouse model of sickle cell disease-Reference-Cited by-同舟云学术

Effect of chronic opioid therapy on pain and survival in a humanized mouse model of sickle cell disease

Published:2019-03-18 Issue:6 Volume:3 Page:869-873
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Tran Huy¹,Sagi Varun¹,Leonce Song-Naba Waogwende¹,Wang Ying¹,Mittal Aditya¹,Lamarre Yann¹,Zhang Lei²,Gupta Kalpna¹

Affiliation:

1. Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, and

2. Biostatistical Design and Analysis Center, Clinical and Translational Sciences Institute, University of Minnesota, Minneapolis, MN

Abstract

Key Points Chronic morphine treatment leads to decreased survival in control mice, but not in sickle mice. Chronic morphine treatment leads to hyperalgesia in sickle mice, but does not lead to analgesic tolerance.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/6/869/1554720/advances024299.pdf

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