Delayed immune reconstitution after allogeneic transplantation increases the risks of mortality and chronic GVHD-Reference-Cited by-同舟云学术

Delayed immune reconstitution after allogeneic transplantation increases the risks of mortality and chronic GVHD

Published:2018-04-20 Issue:8 Volume:2 Page:909-922
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Bejanyan Nelli¹,Brunstein Claudio G.¹,Cao Qing²,Lazaryan Aleksandr¹,Luo Xianghua²,Curtsinger Julie³,Mehta Rohtesh S.¹,Warlick Erica¹,Cooley Sarah A.¹,Blazar Bruce R.³,Miller Jeffrey S.¹,Weisdorf Daniel¹,Wagner John E.³,Verneris Michael R.³

Affiliation:

1. Division of Hematology, Oncology and Transplantation,

2. Biostatistics Core, Masonic Cancer Center, and

3. Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN

Abstract

Key Points UCB recipients have slower T-cell reconstitution but more robust NK and B-cell recovery after allo-HCT than MSD recipients. Delayed CD4+ total and naive T-cell reconstitution after allo-HCT increases the risk of infection, mortality, and chronic GVHD.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/8/909/880819/advances014464.pdf

Reference66 articles.

1. Serious infection risk and immune recovery after double-unit cord blood transplantation without antithymocyte globulin;Sauter;Biol. Blood Marrow Transplant.,2011

2. Severe infections after unrelated donor allogeneic hematopoietic stem cell transplantation in adults: comparison of cord blood transplantation with peripheral blood and bone marrow transplantation;Parody;Biol. Blood Marrow Transplant.,2006

3. Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing;Komanduri;Blood,2007

4. Outcomes, infections, and immune reconstitution after double cord blood transplantation in patients with high-risk hematological diseases;Ruggeri;Transpl Infect Dis.,2011

5. Immune reconstitution after double umbilical cord blood stem cell transplantation: comparison with unrelated peripheral blood stem cell transplantation;Jacobson;Biol. Blood Marrow Transplant.,2012

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