Immune signatures associated with improved progression-free and overall survival for myeloma patients treated with AHSCT

Author:

Ho Christine M.1,McCarthy Philip L.1ORCID,Wallace Paul K.2,Zhang Yali1,Fora Ahmad1,Mellors Patrick1,Tario Joseph D.2,McCarthy Benjamin L. S.1,Chen George L.1,Holstein Sarah A.3,Balderman Sophia R.1,Cao Xuefang4,Paiva Bruno5,Hahn Theresa1

Affiliation:

1. Department of Medicine and

2. Department of Flow and Image Cytometry, Roswell Park Cancer Institute, Buffalo, NY;

3. Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE;

4. Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY; and

5. Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain

Abstract

Key Points Specific immune phenotypes were predictive of long-term survival for MM patients undergoing transplantation. MRD status and use of maintenance therapy were associated with unique immune profiles predictive of outcome.

Publisher

American Society of Hematology

Subject

Hematology

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