Safety, pharmacokinetics, and reversal of apixaban anticoagulation with andexanet alfa-Reference-Cited by-同舟云学术

Safety, pharmacokinetics, and reversal of apixaban anticoagulation with andexanet alfa

Published:2017-09-22 Issue:21 Volume:1 Page:1827-1838
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Siegal Deborah¹,Lu Genmin²,Leeds Janet M.²,Karbarz Mark²,Castillo Janice²,Mathur Vandana³,Hutchaleelaha Athiwat²,Sinha Uma²,Kitt Michael²,McClure Matt²,Hollenbach Stanley J.²,Curnutte John T.²,Conley Pamela B.²,Crowther Mark¹

Affiliation:

1. Department of Medicine, McMaster University, Hamilton, ON, Canada;

2. Portola Pharmaceuticals, San Francisco, CA; and

3. Mathur Consulting, San Francisco, CA

Abstract

Key Points Andexanet reversed apixaban anticoagulation in healthy volunteers within minutes after administration and for the duration of infusion. Andexanet was generally well tolerated, with no evidence of prothrombotic activity in preclinical models and in healthy subjects.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/21/1827/878904/advances007112.pdf

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