Risk of disease transformation and second primary solid tumors in patients with myeloproliferative neoplasms

Author:

Hong Junshik1ORCID,Lee Ju Hyun2,Byun Ja Min1,Lee Ji Yun2,Koh Youngil1,Shin Dong-Yeop1,Lee Jeong-Ok2,Hwang Sang Mee3ORCID,Choi Hyoung Soo4ORCID,Kim Inho1,Yoon Sung-Soo1ORCID,Bang Soo-Mee2

Affiliation:

1. Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea; and

2. Department of Internal Medicine,

3. Department of Laboratory Medicine, and

4. Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam National University College of Medicine, Seongnam, South Korea

Abstract

Key Points South Korean MPN patients had a significantly higher risk of developing second primary solid tumors than that of the general population. Patients with SMF had an overall survival comparable to those with PMF with less risk of developing SAML.

Publisher

American Society of Hematology

Subject

Hematology

Reference34 articles.

1. Myeloproliferative neoplasms: a contemporary review;Tefferi;JAMA Oncol,2015

2. Polycythemia vera and essential thrombocythemia: 2017 update on diagnosis, risk-stratification, and management;Tefferi;Am J Hematol,2017

3. Recent advances in the diagnosis and management of primary myelofibrosis;Takenaka;Korean J Intern Med (Korean Assoc Intern Med),2018

4. A population-based analysis of second malignancies among patients with myeloproliferative neoplasms in the SEER database;Brunner;Leuk Lymphoma,2016

5. Second malignancies in patients with myeloproliferative neoplasms: a population-based cohort study of 9379 patients;Landtblom;Leukemia,2018

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