Whole-genome sequencing reveals potent therapeutic strategy for monomorphic epitheliotropic intestinal T-cell lymphoma-Reference-Cited by-同舟云学术

Whole-genome sequencing reveals potent therapeutic strategy for monomorphic epitheliotropic intestinal T-cell lymphoma

Published:2020-10-05 Issue:19 Volume:4 Page:4769-4774
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Huang Dachuan¹²,Lim Jing Quan¹²^ORCID,Cheah Daryl Ming Zhe¹,Kahliab Khalilatul Hanisah Binte Mohd¹^ORCID,Laurensia Yurike¹,Pang Jane Wan Lu¹,Wong Esther Kam Yin¹,Chia Burton Kuan Hui¹,Goh Jasmine³,Zhang Xiyun³,Chan Jason Yongsheng⁴^ORCID,Chow Edward Kai-Hua³,Tan Soo Yong⁵^ORCID,Lim Soon Thye²⁴⁶^ORCID,Ong Choon Kiat¹²⁷^ORCID

Affiliation:

1. Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, National Cancer Centre, Singapore;

2. Duke-NUS Medical School, Singapore;

3. Cancer Science Institute of Singapore, National University of Singapore, Singapore;

4. Division of Medical Oncology, National Cancer Centre Singapore, Singapore;

5. National University of Singapore Yong Loo Lin School of Medicine, Singapore;

6. SingHealth Duke-NUS Blood Cancer Centre, Singapore; and

7. Genome Institute of Singapore, Singapore

Abstract

Key Points Whole genomic and transcriptomic analyses of MEITL revealed multiple potential therapeutic targets. Synergistic effects of pimozide and romidepsin are shown in a well-characterized MEITL PDX model.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/4/19/4769/1760428/advancesadv2020001782.pdf

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