Targeting the deacetylase SIRT6 unveils spliceosome deregulation as exploitable vulnerability for aggressive myeloma-Reference-Cited by-同舟云学术

Targeting the deacetylase SIRT6 unveils spliceosome deregulation as exploitable vulnerability for aggressive myeloma

Published:2023-07-13 Issue:14 Volume:7 Page:3472-3478
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Gelli Elisa¹,Soncini Debora¹,Becherini Pamela¹²,Martinuzzi Claudia²,Todoerti Katia³,Cagnetta Antonia¹²^ORCID,Aquino Sara⁴,Guolo Fabio¹²,Miglino Maurizio¹²,Bruzzone Santina⁵,Nencioni Alessio⁶,Neri Antonino⁷,Lemoli Roberto M.¹²,Cea Michele¹²^ORCID

Affiliation:

1. 1Clinic of Hematology, Department of Internal Medicine, University of Genoa, Genoa, Italy

2. 2IRCCS Ospedale Policlinico San Martino, Genoa, Italy

3. 3Department of Hematology, Fondazione Cà Granda IRCCS Policlinico, Milan, Italy

4. 4Division of Hematology and Hematopoietic Stem Cell Transplantation Unit, Ospedale Policlinico San Martino, Genoa, Italy

5. 5Department of Experimental Medicine, University of Genova, Genova, Italy

6. 6Department of Internal Medicine, University of Genoa, Genoa, Italy

7. 7Scientific Directorate, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy

Publisher

American Society of Hematology

Subject

Hematology

Link

https://ashpublications.org/bloodadvances/article-pdf/7/14/3472/2065201/blooda_adv-2022-009035-main.pdf

Reference23 articles.

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3. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism;Sebastian;Cell,2012

4. SIRT6 suppresses pancreatic cancer through control of Lin28b;Kugel;Cell,2016

5. Liver cancer initiation is controlled by AP1 through SIRT6-dependent inhibition of surviving;Min;Nat Cell Biol,2012