Innate transcriptional effects by adjuvants on the magnitude, quality, and durability of HIV envelope responses in NHPs

Author:

Francica Joseph R.1,Zak Daniel E.2,Linde Caitlyn3,Siena Emilio45,Johnson Carrie2,Juraska Michal6,Yates Nicole L.7,Gunn Bronwyn3,De Gregorio Ennio45,Flynn Barbara J.1,Valiante Nicholas M.48,Malyala Padma4,Barnett Susan W.49,Sarkar Pampi4,Singh Manmohan410,Jain Siddhartha4,Ackerman Margaret11,Alam Munir7,Ferrari Guido7,Salazar Andres12,Tomaras Georgia D.7,O’Hagan Derek T.45,Aderem Alan2,Alter Galit3,Seder Robert A.1

Affiliation:

1. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD;

2. The Center for Infectious Disease Research, Seattle, WA;

3. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA;

4. Novartis Vaccines and Diagnostics, Cambridge, MA;

5. GlaxoSmithKline, Siena, Italy;

6. Statistical Center for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

7. Duke Human Vaccine Institute, Durham, NC;

8. Moderna Therapeutics, Cambridge, MA;

9. Bill & Melinda Gates Foundation, Washington, DC;

10. Takeda Pharmaceuticals, Cambridge, MA;

11. Thayer School of Engineering, Dartmouth College, Hanover, NH; and

12. Oncovir, Inc, Washington, DC

Abstract

Key PointsTLR4 and 7 agonists improve titers when coformulated with alum but not an emulsion formulation, but do not impact the titer half-lives. Alum/TLR7 and pIC:LC are potent adjuvant formulations that improve the magnitude and quality of humoral and cellular responses to HIV Env.

Publisher

American Society of Hematology

Subject

Hematology

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