Pembrolizumab in mycosis fungoides with PD-L1 structural variants

Author:

Beygi Sara1,Fernandez-Pol Sebastian2ORCID,Duran George1ORCID,Wang Erica B.3,Stehr Henning2,Zehnder James L.2,Ramchurren Nirasha4,Fling Steven P.4ORCID,Cheever Martin A.4ORCID,Weng Wen-Kai35,Kim Youn H.13,Khodadoust Michael S.13ORCID

Affiliation:

1. Division of Medical Oncology, Department of Medicine,

2. Department of Pathology, and

3. Department of Dermatology, Stanford University, Stanford, CA;

4. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA; and

5. Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University, Stanford, CA

Abstract

Key Points PD-L1 structural variants are recurrent in mycosis fungoides with large cell transformation. PD-L1 structural variants in relapsed/refractory mycosis fungoides should prompt consideration of treatment with PD-1 inhibitors.

Publisher

American Society of Hematology

Subject

Hematology

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