Biocompatible coupling of therapeutic fusion proteins to human erythrocytes-Reference-Cited by-同舟云学术

Biocompatible coupling of therapeutic fusion proteins to human erythrocytes

Published:2018-01-24 Issue:3 Volume:2 Page:165-176
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Villa Carlos H.¹²,Pan Daniel C.²,Johnston Ian H.²³,Greineder Colin F.²,Walsh Landis R.²,Hood Elizabeth D.²,Cines Douglas B.¹,Poncz Mortimer³,Siegel Don L.¹,Muzykantov Vladimir R.²

Affiliation:

1. Department of Pathology and Laboratory Medicine and

2. Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and

3. Division of Pediatric Hematology, Children’s Hospital of Philadelphia, Philadelphia, PA

Abstract

Key PointsThrombomodulin was fused to scFvs targeting RhCE (Rh17 epitope) and band 3/GPA (Wrb epitope). Fusion proteins were efficacious in a humanized microfluidic model of inflammatory thrombosis.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/3/165/880176/advances011734.pdf

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