Patients with spontaneous remission of high-risk MDS and AML show persistent preleukemic clonal hematopoiesis-Reference-Cited by-同舟云学术

Patients with spontaneous remission of high-risk MDS and AML show persistent preleukemic clonal hematopoiesis

Published:2019-09-12 Issue:18 Volume:3 Page:2696-2699
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Grunwald Victoria V.¹,Hentrich Marcus²,Schiel Xaver³,Dufour Annika¹,Schneider Stephanie¹,Neusser Michaela¹^ORCID,Subklewe Marion¹,Fiegl Michael¹,Hiddemann Wolfgang¹,Spiekermann Karsten¹,Rothenberg-Thurley Maja¹,Metzeler Klaus H.¹^ORCID

Affiliation:

1. Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, University Hospital, LMU Munich, Munich, Germany;

2. Department of Internal Medicine, Hematology and Oncology, Red Cross Hospital, Munich, Germany; and

3. Department of Oncology, Hematology and Palliative Care, Klinikum Harlaching, Munich, Germany

Abstract

Key Points We report longitudinal mutational analyses of 2 patients with high-risk MDS and AML experiencing spontaneous disease remissions. Both patients had persistent clonal hematopoiesis during remission, harboring all but 1 of the mutations from the initial diagnostic sample.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/18/2696/1223250/advancesadv2019000265.pdf

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