IL-6 levels are dramatically high in the sputum from children with sickle cell disease during acute chest syndrome

Author:

Allali Slimane123ORCID,de Montalembert Mariane134ORCID,Rignault-Bricard Rachel2,Taylor Melissa13,Brice Joséphine134,Brousse Valentine134ORCID,Talbot Jean-Marc1,Moulin Florence5,Heilbronner Claire5,Hermine Olivier236,Maciel Thiago Trovati23

Affiliation:

1. Department of General Pediatrics and Pediatric Infectious Diseases, Reference Center for Sickle Cell Disease, Necker Hospital for Sick Children, Assistance Publique–Hôpitaux de Paris (AP-HP), Université de Paris, Paris, France;

2. Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Université de Paris, Imagine Institute, INSERM U1163, Paris, France;

3. Laboratory of Excellence GR-Ex, Paris, France;

4. Institut National de la Transfusion Sanguine, INSERM UMR_S 1134, Paris, France; and

5. Pediatric Intensive Care Unit and

6. Department of Hematology, Necker Hospital for Sick Children, AP-HP, Université de Paris, Paris, France

Abstract

Key Points Sputum interleukin-6 (IL-6) level is high during acute chest syndrome (ACS) in pediatric sickle cell disease, supporting anti–IL-6 trials. Sputum IL-8, CCL2, and CCL3 levels are also high during ACS, possibly contributing to recruitment of inflammatory cells in the lungs.

Publisher

American Society of Hematology

Subject

Hematology

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