Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice-Reference-Cited by-同舟云学术

Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice

Published:2019-12-10 Issue:23 Volume:3 Page:4104-4116
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Wood Katherine C.¹,Durgin Brittany G.¹^ORCID,Schmidt Heidi M.¹²^ORCID,Hahn Scott A.¹,Baust Jeffrey J.¹,Bachman Tim¹,Vitturi Dario A.¹²^ORCID,Ghosh Samit¹^ORCID,Ofori-Acquah Solomon F.¹³,Mora Ana L.¹⁴^ORCID,Gladwin Mark T.¹⁴,Straub Adam C.¹²

Affiliation:

1. Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, Department of Medicine,

2. Department of Pharmacology and Chemical Biology,

3. Division of Hematology and Oncology, Department of Medicine, and

4. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA

Abstract

Key PointsVascular SMC CYB5R3 delays development of SCD-associated PH in mice. PH in SCD can exist in mice by 5 weeks of age when SMC CYB5R3 protein is deficient.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/23/4104/1547223/advancesadv2019000621.pdf

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