Clinical and functional impact of recurrent S1PR1 mutations in mantle cell lymphoma-Reference-Cited by-同舟云学术

Clinical and functional impact of recurrent S1PR1 mutations in mantle cell lymphoma

Published:2018-03-16 Issue:6 Volume:2 Page:621-625
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Wasik Agata M.¹,Wu Chenglin²,Mansouri Larry³⁴,Rosenquist Richard³⁴,Pan-Hammarström Qiang²,Sander Birgitta¹

Affiliation:

1. Division of Pathology and

2. Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden;

3. Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden; and

4. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

Abstract

Key Points S1PR1 mutations are present in 7.8% of patients with MCL and are significantly more frequent at relapse. S1PR1 mutations reduce expression of the S1PR1 receptor, which mediates migration towards the tissue-to-blood egress factor S1P in MCL.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/6/621/882770/advances014860.pdf

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