Role of the hepcidin-ferroportin axis in pathogen-mediated intracellular iron sequestration in human phagocytic cells-Reference-Cited by-同舟云学术

Role of the hepcidin-ferroportin axis in pathogen-mediated intracellular iron sequestration in human phagocytic cells

Published:2018-05-15 Issue:10 Volume:2 Page:1089-1100
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Abreu Rodrigo¹^ORCID,Quinn Frederick¹,Giri Pramod K.¹

Affiliation:

1. Department of Infectious Diseases, University of Georgia, Athens, GA

Abstract

Key Points TLR signaling induces intracellular iron sequestration in macrophages through 2 redundant mechanisms. TLR2 signaling downregulates ferroportin transcriptional expression, whereas TLR4 induces hepcidin secretion.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/10/1089/879951/advances015255.pdf

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