TLR2 agonism reverses chemotherapy-induced neutropenia in Macaca fascicularis-Reference-Cited by-同舟云学术

TLR2 agonism reverses chemotherapy-induced neutropenia in Macaca fascicularis

Published:2017-12-08 Issue:26 Volume:1 Page:2553-2562
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Laping Nicholas J.¹,DeMartino Michael P.¹,Cottom Joshua E.²,Axten Jeffrey M.¹,Emery John G.¹,Guss Jeffrey H.²,Burman Miriam²,Foley James J.²,Cheung Mui¹,Oliff Allen¹,Kumar Sanjay¹

Affiliation:

1. New Targets Incubator and

2. PTS–Biological Sciences, GlaxoSmithKline, King of Prussia, PA

Abstract

Key PointsA novel TLR2 agonist was identified that stimulates the release of G-CSF, IL-6, and monocyte chemoattractant protein 1. This agonist increases neutrophil numbers in a primate model of neutropenia.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/26/2553/880012/advances010611.pdf

Reference43 articles.

1. Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients;Kuderer;Cancer,2006

2. Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor;Nagata;Nature,1986

3. Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells;Souza;Science,1986

4. Treatment of chemotherapy-induced neutropenia by subcutaneously administered granulocyte colony-stimulating factor with optimization of dose and duration of therapy;Morstyn;J Clin Oncol,1989

5. Effect of peripheral-blood progenitor cells mobilised by filgrastim (G-CSF) on platelet recovery after high-dose chemotherapy;Sheridan;Lancet,1992

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