Prognostic significance of cytogenetic heterogeneity in patients with newly diagnosed multiple myeloma

Author:

Merz Maximilian1,Jauch Anna2,Hielscher Thomas3,Bochtler Tilmann1,Schönland Stefan Olaf1,Seckinger Anja1,Hose Dirk1,Bertsch Uta14,Neben Kai1,Raab Marc Steffen15,Hillengass Jens1,Salwender Hans6,Blau Igor Wolfgang7,Lindemann Hans-Walter8,Schmidt-Wolf Ingo G. H.9,Scheid Christof10,Haenel Mathias11,Weisel Katja C.12,Goldschmidt Hartmut14

Affiliation:

1. Medizinische Klinik V and

2. Institute of Human Genetics, University Hospital of Heidelberg, Heidelberg, Germany;

3. Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany;

4. National Center for Tumor Diseases, Heidelberg, Germany;

5. Max-Eder Research Group Experimental Therapies for Hematologic Malignancies, DKFZ, Heidelberg, Germany;

6. Asklepios Klinik Altona, Hamburg, Germany;

7. Department of Internal Medicine III, Charité Campus Benjamin Franklin, Berlin, Germany;

8. Hämatologie/Onkologie, Katholisches Krankenhaus Hagen gemeinnützige GmbH–St.-Marien-Hospital, Hagen, Germany;

9. Center for Integrated Oncology, Medizinische Klinik und Poliklinik III, University of Bonn, Bonn, Germany;

10. Department of Internal Medicine I, University of Cologne, Cologne, Germany;

11. Klinikum Chemnitz gGmbH, Chemnitz, Germany; and

12. University Hospital of Tuebingen, Tuebingen, Germany

Abstract

Key Points Clonal heterogeneity detected by iFISH is common in newly diagnosed MM. Treatment with bortezomib overcomes the negative impact of high-risk cytogenetic abnormalities if no further subclones are detected.

Publisher

American Society of Hematology

Subject

Hematology

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