The impact of von Willebrand factor on factor VIII memory immune responses

Author:

Chen Juan1,Schroeder Jocelyn A.123,Luo Xiaofeng1,Shi Qizhen1234

Affiliation:

1. Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI;

2. Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI;

3. Children’s Research Institute, Children’s Hospital of Wisconsin, Milwaukee, WI; and

4. MACC Fund Research Center, Milwaukee, WI

Abstract

Key Points VWF attenuates primed T-cell proliferation and memory B-cell differentiation. VWF mitigates FVIII memory responses in FVIIInull mice.

Publisher

American Society of Hematology

Subject

Hematology

Reference46 articles.

1. Von Willebrand factor: dissociation from antihemophilic factor procoagulant activity;Weiss;Science,1973

2. Cell biology of von Willebrand factor;Wagner;Annu Rev Cell Biol,1990

3. The role of von Willebrand factor multimers and propeptide cleavage in binding and stabilization of factor VIII;Wise;J Biol Chem,1991

4. Regulation of factor VIII expression and activity by von Willebrand factor;Kaufman;Thromb Haemost,1999

5. How we choose factor VIII to treat hemophilia;Mannucci;Blood,2012

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