Quantitative proteomics of plasma vesicles identify novel biomarkers for hemoglobin E/β-thalassemic patients-Reference-Cited by-同舟云学术

Quantitative proteomics of plasma vesicles identify novel biomarkers for hemoglobin E/β-thalassemic patients

Published:2018-01-16 Issue:2 Volume:2 Page:95-104
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Kittivorapart Janejira¹²³,Crew Vanja Karamatic²,Wilson Marieangela C.³⁴,Heesom Kate J.⁴,Siritanaratkul Noppadol⁵,Toye Ashley M.²³⁶^ORCID

Affiliation:

1. Department of Transfusion Medicine, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand;

2. Bristol Institute for Transfusion Sciences, National Health Service Blood and Transplant, Bristol, United Kingdom;

3. School of Biochemistry and

4. Proteomics Facility, University of Bristol, Bristol, United Kingdom;

5. Department of Medicine Faculty of Medicine Siriraj Hospital, Bangkok, Thailand; and

6. National Institute for Health Research Blood and Transplant Unit in Red Blood Cell Products, University of Bristol, Bristol, United Kingdom

Abstract

Key PointsChaperones, antioxidants, iron-sequestering proteins, and cathepsin S exhibited increased abundance in thalassemic EVs. Haptoglobin and hemopexin are reduced in thalassemic patients’ EVs, reflecting hemolysis. These could be used as clinical biomarkers.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/2/95/879805/advances011726.pdf

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