Lenalidomide consolidation benefits patients with CLL receiving chemoimmunotherapy: results for CALGB 10404 (Alliance)

Author:

Byrd John C.1,Ruppert Amy S.12,Heerema Nyla A.3,Halvorson Alese E.4,Hoke Eva5,Smith Mitchell R.6,Godwin John E.7,Couban Stephen8,Fehniger Todd A.9,Thirman Michael J.10,Tallman Martin S.11,Appelbaum Frederick R.12,Stone Richard M.13,Robinson Sue8,Chang Julie E.14,Mandrekar Sumithra J.4,Larson Richard A.10

Affiliation:

1. Division of Hematology,

2. Alliance Statistics and Data Center, and

3. Department of Pathology, The Ohio State University, Columbus, OH;

4. Alliance Statistics and Data Center, Mayo Clinic, Rochester, MN;

5. Alliance Statistics and Data Center, Duke University, Durham, NC;

6. Department of Medical Oncology and Hematology, George Washington University Cancer Center, Washington, DC;

7. Providence Cancer Center, Portland, OR;

8. QEII Health Sciences Centre, Halifax, NS, Canada;

9. Division of Oncology, Washington University School of Medicine, St. Louis, MO;

10. Department of Medicine, University of Chicago Comprehensive Cancer Center, Chicago, IL;

11. Memorial Sloan Kettering Cancer Center, New York, NY;

12. Fred Hutchinson Cancer Research Center, Seattle, WA;

13. Dana-Farber/Partners CancerCare, Harvard Cancer Center, Boston, MA; and

14. Department of Medicine, University of Wisconsin, Madison, WI

Abstract

Key Points Brief lenalidomide consolidation after chemoimmunotherapy is acceptably tolerated and extends PFS and OS in CLL. FCR has superior efficacy compared with FR chemoimmunotherapy for CLL.

Publisher

American Society of Hematology

Subject

Hematology

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