Detrimental effects of sickle cell disease and hydroxycarbamide on ovarian reserve but uncertain impact on fertility

Author:

Joseph Laure1,Manceau Sandra12,Borderie Didier34ORCID,Patrat Catherine35ORCID,Arlet Jean Benoit6,Meunier Benoit1,Cavazzana Marina17ORCID,Santulli Pietro389,Barraud-Lange Virginie359

Affiliation:

1. 1Biotherapy Department, French National Sickle Cell Referral Center, Clinical Investigation Center, Hôpital Necker, Assistance-Publique Hôpitaux de Paris, Paris, France

2. 2Laboratory of Excellence on Red Blood Cell Labex GR-Ex, Paris, France

3. 3University of Paris Cité, Paris, France

4. 4Automated Biological Diagnosis Department, AP-HP.Centre-University of Paris Cité, Cochin Hospital, Paris, France

5. 5Department of Reproductive Biology CECOS, AP-HP.Centre-University of Paris Cité, Cochin Hospital, Paris, France

6. 6Internal Medicine Department, French National Sickle Cell Referral Center, Hôpital Européen Georges Pompidou, Assistance-Publique Hôpitaux de Paris, Paris, France

7. 7INSERM U1163, CNRS 8254, Institut IMAGINE, Hôpital Necker, Assistance-Publique Hôpitaux de Paris, Paris, France

8. 8Department of Gynecology Obstetrics II and Reproductive Medicine, AP-HP.Centre-University of Paris Cité, Cochin Hospital, Paris, France

9. 9Department “Development, Reproduction and Cancer” Institut Cochin, INSERM U1016, Paris, France

Publisher

American Society of Hematology

Subject

Hematology

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