B-cell acute lymphoblastic leukemia with high mutation burden presenting in a child with constitutional mismatch repair deficiency-Reference-Cited by-同舟云学术

B-cell acute lymphoblastic leukemia with high mutation burden presenting in a child with constitutional mismatch repair deficiency

Published:2019-06-12 Issue:12 Volume:3 Page:1795-1798
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Oshrine Benjamin¹,Grana Nanette¹,Moore Colin¹,Nguyen Johnny¹,Crenshaw Melissa¹,Edwards Melissa²,Sudhaman Sumedha²,Forster Victoria J.²,Tabori Uri²

Affiliation:

1. Johns Hopkins All Children’s Hospital, St. Petersburg, FL; and

2. The Hospital for Sick Children, Toronto, ON, Canada

Abstract

Key Points Constitutional mismatch repair deficiency syndrome should be considered in children with acute leukemia and characteristic skin lesions. The high mutation burden of CMMRD-related cancers contributes to treatment resistance, necessitating individualized treatment strategies.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/12/1795/1555071/advancesadv2019000358.pdf

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