Blockade of CD7 expression in T cells for effective chimeric antigen receptor targeting of T-cell malignancies-Reference-Cited by-同舟云学术

Blockade of CD7 expression in T cells for effective chimeric antigen receptor targeting of T-cell malignancies

Published:2017-11-21 Issue:25 Volume:1 Page:2348-2360
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Png Yi Tian¹^ORCID,Vinanica Natasha¹,Kamiya Takahiro¹,Shimasaki Noriko¹,Coustan-Smith Elaine¹,Campana Dario¹

Affiliation:

1. Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Abstract

Key Points Blockade of CD7 expression with a novel method, combined with a second-generation CAR, results in highly potent anti-CD7 CAR T cells. This practical strategy provides a new treatment option for patients with high-risk T-cell malignancies, including ETP-ALL.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/25/2348/879337/advances009928.pdf

Reference56 articles.

1. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors;Eshhar;Proc Natl Acad Sci USA,1993

2. The TCR zeta-chain immunoreceptor tyrosine-based activation motifs are sufficient for the activation and differentiation of primary T lymphocytes;Geiger;J Immunol,1999

3. Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15;Brentjens;Nat Med,2003

4. T-cell clones can be rendered specific for CD19: toward the selective augmentation of the graft-versus-B-lineage leukemia effect;Cooper;Blood,2003

5. Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia;Imai;Leukemia,2004

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