Evolution, trends, outcomes, and economics of hematopoietic stem cell transplantation in severe autoimmune diseases

Author:

Snowden John A.1,Badoglio Manuela2,Labopin Myriam3,Giebel Sebastian4,McGrath Eoin5,Marjanovic Zora6,Burman Joachim7,Moore John8,Rovira Montserrat9,Wulffraat Nico M.10,Kazmi Majid11,Greco Raffaella12,Snarski Emilian13,Kozak Tomas14,Kirgizov Kirill15,Alexander Tobias16,Bader Peter17,Saccardi Riccardo18,Farge Dominique1920

Affiliation:

1. Department of Haematology, Sheffield Teaching Hospitals National Health Service Foundation Trust, Sheffield, United Kingdom;

2. European Society for Blood and Marrow Transplantation (EBMT) Paris Study Office and

3. Department of Haematology, Saint Antoine Hospital, INSERM Unité Mixte de Recherche 938, Université Pierre et Marie Curie, Paris, France;

4. Department of Bone Marrow Transplantation and Onco-Hematology, Maria Sklodowska-Curie Institute–Oncology Center, Gliwice Branch, Gliwice, Poland;

5. Joint Accreditation Committee of the International Society for Cellular Therapy and EBMT (JACIE) Office, Barcelona, Spain;

6. Service d'Hematologie clinique et Therapie Cellulaire, Hopital Saint-Antoine, Assistance Publique–Hôpitaux de Paris (AP-HP), Paris, France;

7. Department of Neuroscience, Uppsala University, Uppsala, Sweden;

8. Haematology Department, St. Vincent’s Health Network, Darlinghurst, NSW, Australia;

9. Department of Haematology, Hospital Clinic, Barcelona, Spain;

10. Divisie Kinderen, Cluster Immunologie, Reumatologie, Hematologie en Infectiologie, Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands;

11. Kings Health Partners, Department of Haematology, Guys Hospital, London, United Kingdom;

12. Hematology and Bone Marrow Transplantation Unit, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Scientific Institute, Milan, Italy;

13. Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland;

14. Přednosta Interní hematologické kliniky, Univerzity Karlovy a Fakultní nemocnice Královské Vinohrady, Prague, Czech Republic;

15. Department of Scientific Studies and Clinical Technologies, Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia;

16. Klinik für Rheumatologie und Klinische Immunologie, Charité-Universitätsmedizin, Berlin, Germany;

17. Stammzelltransplantation und Immunologie Klinik für Kinder und Jugendmedizin, Frankfurt am Main, Germany;

18. Haematology Department, Careggi University Hospital, Florence, Italy;

19. Unité Clinique de Médecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, Unité Fonctionnelle 04, Hôpital Saint-Louis, AP-HP, INSERM Unité Mixte de Recherche Scientifique 1160, Paris Denis Diderot University, Paris, France; and

20. Centre de Référence des Maladies auto-immunes systémiques Rares d’Ile-de-France (site constitutif), Filière FAI2R, Paris, France

Abstract

Key Points Using EBMT data in >2000 patients from 1994 to 2015, we analyzed the development and factors influencing outcomes of HSCT for ADs. Transplant center experience, accreditation, and national socioeconomic factors are relevant for outcomes and future health service delivery.

Publisher

American Society of Hematology

Subject

Hematology

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