Chronic disease burden and frailty in survivors of childhood HSCT: a report from the St. Jude Lifetime Cohort Study

Author:

Eissa Hesham M.12,Lu Lu3,Baassiri Malek1,Bhakta Nickhill134,Ehrhardt Matthew J.13,Triplett Brandon M.5,Green Daniel M.3,Mulrooney Daniel A.13,Robison Leslie L.3,Hudson Melissa M.13,Ness Kirsten K.3

Affiliation:

1. Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN;

2. Department of Pediatrics, University of Minnesota, Minneapolis, MN; and

3. Department of Epidemiology and Cancer Control,

4. Department of Global Pediatric Medicine, and

5. Department of Bone Marrow Transplant and Cellular Therapy, St. Jude Children’s Research Hospital, Memphis, TN

Abstract

Key Points Childhood HSCT survivors suffer from a higher burden of severe/life-threatening conditions compared to conventional therapy survivors. Seven percent of HSCT survivors exhibit frailty phenotype at early age, placing them at higher risk for early mortality.

Publisher

American Society of Hematology

Subject

Hematology

Reference23 articles.

1. Pasquini MC , ZhuX. Current use and outcome of hematopoietic stem cell transplantation: CIBMTR summary slides. https://www.cibmtr.org/ReferenceCenter/SlidesReports/SummarySlides/Documents/2014_Summary_Slides.pptx. Accessed 15 January 2015.

2. Long-term survival after transplantation of unrelated donor peripheral blood or bone marrow hematopoietic cells for hematologic malignancy;Eapen;Biol Blood Marrow Transplant,2015

3. Long-term survival and late deaths after allogeneic hematopoietic cell transplantation;Wingard;J Clin Oncol,2011

4. Clinical ascertainment of health outcomes among adults treated for childhood cancer;Hudson;JAMA,2013

5. Prospective medical assessment of adults surviving childhood cancer: study design, cohort characteristics, and feasibility of the St. Jude Lifetime Cohort study;Hudson;Pediatr Blood Cancer,2011

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