Maternal microchimerism protects hemophilia A patients from inhibitor development-Reference-Cited by-同舟云学术

Maternal microchimerism protects hemophilia A patients from inhibitor development

Published:2020-05-06 Issue:9 Volume:4 Page:1867-1869
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Lu Yeling¹²^ORCID,Chen Zhenping³,Dai Jing¹,Wu Xi¹,Gu Hao³^ORCID,Li Zekun³^ORCID,Li Jian⁴,Ding Qiulan¹⁵,Wu Wenman¹⁴⁵,Wu Runhui³,Wang Xuefeng¹⁴⁵

Affiliation:

1. Department of Clinical Laboratory Medicine and

2. Faculty of Laboratory Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China;

3. Hematology Oncology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China; and

4. Clinical Research Center, Ruijin Hospital, and

5. Collaborative Innovation Center of Hematology, Shanghai Jiaotong University School of Medicine, Shanghai, China

Abstract

Key Points Deleterious F8 mutations do not necessarily lead to the incidence of inhibitors in hemophilia A patients receiving replacement therapy. Maternal chimeric cells migrated into a fetus with hemophilia A during pregnancy could induce tolerance toward FVIII.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/4/9/1867/1727313/advancesadv2020001832.pdf

Reference20 articles.

1. FVIII inhibitors: pathogenesis and avoidance;Astermark;Blood,2015

2. Risk factors for inhibitor development in severe hemophilia;Garagiola;A. Thromb Res,2018

3. Factor VIII brand and the incidence of factor VIII inhibitors in previously untreated UK children with severe hemophilia A, 2000-2011;Collins;Blood,2014

4. Influence of the type of F8 gene mutation on inhibitor development in a single centre cohort of severe haemophilia A patients;Gouw;Haemophilia,2011

5. Unraveling the genetics of inhibitors in hemophilia;Gouw;Blood,2013

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1. Maternal Microchimerism Promotes Tolerance Induction Toward Factor VIII in Severe Haemophilia a Children with Inhibitors;2024

2. Hemophilia a patients with inhibitors: Mechanistic insights and novel therapeutic implications;Frontiers in Immunology;2022-12-08

3. Molecular biology analysis of ABO blood group variants caused by natural chimaerism;Vox Sanguinis;2022-09-14

4. Savior Siblings Might Rescue Fetal Lethality But Not Adult Lymphoma in Irf2bp2-Null Mice;Frontiers in Immunology;2022-07-04