Tranexamic acid is an active site inhibitor of urokinase plasminogen activator-Reference-Cited by-同舟云学术

Tranexamic acid is an active site inhibitor of urokinase plasminogen activator

Published:2019-02-27 Issue:5 Volume:3 Page:729-733
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Wu Guojie¹²^ORCID,Mazzitelli Blake A.¹²,Quek Adam J.¹²^ORCID,Veldman Matthew J.¹²,Conroy Paul J.¹²^ORCID,Caradoc-Davies Tom T.¹²³^ORCID,Ooms Lisa M.¹²^ORCID,Tuck Kellie L.⁴,Schoenecker Jonathan G.⁵^ORCID,Whisstock James C.¹²⁶^ORCID,Law Ruby H. P.¹²^ORCID

Affiliation:

1. ARC Centre of Excellence in Advanced Molecular Imaging, and

2. Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Australia;

3. Australian Synchrotron, Clayton, Australia;

4. School of Chemistry, Monash University, Melbourne, Australia;

5. Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN; and

6. South East University–Monash Joint Institute, Institute of Life Sciences, Southeast University, Nanjing, China

Abstract

Key Points TXA is an active-site inhibitor of uPA. TXA attenuates MDA-MB-231 BAG cell migration and inhibits endogenous uPA activity.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/5/729/1631230/advances025429.pdf

Reference23 articles.

1. New insights into the structure and function of the plasminogen/plasmin system;Law;Curr Opin Struct Biol,2013

2. The x-ray crystal structure of full-length human plasminogen;Law;Cell Reports,2012

3. The binding of tranexamic acid to native (Glu) and modified (Lys) human plasminogen and its effect on conformation;Markus;J Biol Chem,1979

4. An in vitro study of the effects of t-PA and tranexamic acid on whole blood coagulation and fibrinolysis;Godier,2017

5. A comparison of aprotinin and lysine analogues in high-risk cardiac surgery;Fergusson;N Engl J Med,2008

Cited by 26 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A single intraarticular injection of a tranexamic acid-modified hyaluronic acid (HA/TXA) alleviates pain and reduces OA development in a murine model of monosodium iodoacetate-induced osteoarthritis;Frontiers in Pharmacology;2024-09-11

2. The Impact of Tranexamic Acid on Blood Loss Management in Primary Total Knee Arthroplasty: A Comprehensive Review;Cureus;2024-07-25

3. Packaging of supplemented urokinase into alpha granules of in vitro–grown megakaryocytes for targeted nascent clot lysis;Blood Advances;2024-07-12

4. The emerging role of tranexamic acid and its principal target, plasminogen, in skeletal health;Acta Pharmaceutica Sinica B;2024-07

5. Unravelling the Antifibrinolytic Mechanism of Action of the 1,2,3-Triazole Derivatives;International Journal of Molecular Sciences;2024-06-26