Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasms-Reference-Cited by-同舟云学术

Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasms

Published:2017-06-14 Issue:15 Volume:1 Page:1001-1015
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Ueda Koki¹,Ikeda Kazuhiko¹²,Ikezoe Takayuki¹,Harada-Shirado Kayo¹²,Ogawa Kazuei¹,Hashimoto Yuko³,Sano Takahiro¹,Ohkawara Hiroshi¹,Kimura Satoshi¹,Shichishima-Nakamura Akiko¹,Nakamura Yuichi⁴,Shikama Yayoi⁵,Mori Tsutomu⁶,Mason Philip J.⁷,Bessler Monica⁷,Morishita Soji⁸,Komatsu Norio⁸,Shide Kotaro⁹,Shimoda Kazuya⁹,Koide Shuhei¹⁰,Aoyama Kazumasa¹⁰,Oshima Motohiko¹⁰,Iwama Atsushi¹⁰,Takeishi Yasuchika⁴

Affiliation:

1. Department of Hematology,

2. Department of Blood Transfusion and Transplantation Immunology,

3. Department of Diagnostic Pathology,

4. Department of Cardiovascular Medicine, and

5. Department of Pharmacology, Fukushima Medical University, Fukushima, Japan;

6. Department of Human Lifesciences, Fukushima Medical University School of Nursing, Fukushima, Japan;

7. Department of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, PA;

8. Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan;

9. Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan; and

10. Department of Cellular and Molecular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan

Abstract

Key Points In patients with MPNs, repression of MIRlet-7 and mutations in the polycomb genes EZH2 and ASXL1 correlate with HMGA2 overexpression. Hmga2 overexpression collaborates with JAK2V617F to promote lethal MPN in mice, highlighting the crucial role of Hmga2.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/15/1001/878552/advances004457.pdf

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