Agonistic targeting of TLR1/TLR2 induces p38 MAPK-dependent apoptosis and NFκB-dependent differentiation of AML cells-Reference-Cited by-同舟云学术

Agonistic targeting of TLR1/TLR2 induces p38 MAPK-dependent apoptosis and NFκB-dependent differentiation of AML cells

Published:2017-10-18 Issue:23 Volume:1 Page:2046-2057
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Eriksson Mia¹,Peña-Martínez Pablo¹,Ramakrishnan Ramprasad¹,Chapellier Marion¹,Högberg Carl¹,Glowacki Gabriella¹,Orsmark-Pietras Christina¹,Velasco-Hernández Talía²,Lazarević Vladimir Lj³,Juliusson Gunnar³,Cammenga Jörg⁴,Mulloy James C.⁵,Richter Johan³,Fioretos Thoas¹,Ebert Benjamin L.⁶,Järås Marcus¹

Affiliation:

1. Department of Clinical Genetics and

2. Department of Molecular Hematology, Lund University, Lund, Sweden;

3. Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden;

4. Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden;

5. Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH; and

6. Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

Abstract

Key Points TLR1 is upregulated on primitive AML cells. Agonistic targeting of TLR1/TLR2 induces apoptosis and differentiation of primitive AML cells in vivo.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/23/2046/878943/advances006148.pdf

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