Intragenic amplification of PAX5: a novel subgroup in B-cell precursor acute lymphoblastic leukemia?

Author:

Schwab Claire1,Nebral Karin2,Chilton Lucy1,Leschi Cristina34,Waanders Esmé5,Boer Judith M.6,Žaliová Markéta78,Sutton Rosemary9ORCID,Öfverholm Ingegerd Ivanov10,Ohki Kentaro11ORCID,Yamashita Yuka12,Groeneveld-Krentz Stefanie13,Froňková Eva8ORCID,Bakkus Marleen14,Tchinda Joelle15ORCID,Barbosa Thayana da Conceição16,Fazio Grazia17ORCID,Mlynarski Wojciech18,Pastorczak Agata18,Cazzaniga Giovanni17ORCID,Pombo-de-Oliveira Maria S.16,Trka Jan8ORCID,Kirschner-Schwabe Renate1319,Imamura Toshihiko20,Barbany Gisela10,Stanulla Martin21,Attarbaschi Andishe22,Panzer-Grümayer Renate2,Kuiper Roland P.5,den Boer Monique L.623,Cavé Hélène34ORCID,Moorman Anthony V.1,Harrison Christine J.1,Strehl Sabine2ORCID

Affiliation:

1. Leukaemia Research Cytogenetics Group, Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;

2. Children’s Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria;

3. INSERM Unité Mixte de Recherché 1131, Institut Universitaire d’Hématologie, Université Paris Diderot, Paris Sorbonne Cité, Paris, France;

4. Département de Génétique, Hôpital Robert Debré, Assistance Publique–Hôpitaux de Paris, Paris, France;

5. Department of Human Genetics, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands;

6. Department of Pediatric Oncology, Erasmus MC–Sophia Children’s Hospital, Rotterdam, The Netherlands;

7. Department of Pediatrics, University Hospital Schleswig-Holstein, Kiel, Germany;

8. Childhood Leukaemia Investigation Prague, Department of Pediatric Hematology/Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic;

9. Children’s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, Australia;

10. Clinical Genetics Section, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden;

11. Department of Pediatric Hematology and Oncology, National Center for Child Health and Development, Tokyo, Japan;

12. Clinical Research Center, Nagoya Medical Center, National Hospital Organization, Aichi, Japan;

13. Division of Oncology and Hematology, Department of Pediatrics, Charité–Universitätsmedizin Berlin, Berlin, Germany;

14. Department of Hematology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium;

15. Pediatric Oncology, Children’s Research Centre, University Children’s Hospital Zürich, Zürich, Switzerland;

16. Pediatric Hematology-Oncology Program, Research Center, Instituto Nacional de Câncer, Rio de Janeiro, Brazil;

17. Centro Ricerca Tettamanti, Clinica Pediatrica, Università di Milano-Bicocca, Monza, Italy;

18. Department of Pediatrics, Oncology, Hematology and Diabetology, Medical University of Lodz, Lodz, Poland;

19. German Cancer Consortium and German Cancer Research Center, Heidelberg, Germany;

20. Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan;

21. Department of Pediatric Hematology and Oncology, Medical School Hannover, Hannover, Germany;

22. Department of Pediatric Hematology and Oncology, St Anna Children’s Hospital, Medical University of Vienna, Austria; and

23. Dutch Childhood Oncology Group, The Hague, The Netherlands

Abstract

Key Points Intragenic PAX5 amplification defines a novel, relapse-prone subtype of B-cell precursor acute lymphoblastic leukemia with a poor outcome.

Publisher

American Society of Hematology

Subject

Hematology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3