Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S-Reference-Cited by-同舟云学术

Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S

Published:2017-08-07 Issue:18 Volume:1 Page:1423-1426
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Fernández José A.¹,Xu Xiao¹,Sinha Ranjeet K.¹,Mosnier Laurent O.¹,Sanner Michel F.²,Griffin John H.¹

Affiliation:

1. Department of Molecular Medicine and

2. Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA

Abstract

Key Points Protein S anticoagulant cofactor sensitivity and PAR1 cleavage activity were assayed for 9 recombinant APC mutants. Residues L38, K43, I73, F95, and W115 on one face of the APC light chain define an extended surface containing the protein S binding site.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/18/1423/878342/advances007005.pdf

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