Affiliation:
1. Thomas Henry Simpson Memorial Institute for Medical Research, Ann Arbor, Mich.
Abstract
Abstract
The gastric juice and small intestinal secretions of three cases of untreated pernicious anemia and two control patients obtained during a period of fasting contained only very small amounts of pteroylglutamic acid or of factors for the growth of L. leichmannii, which include vitamin B12; there was no evidence of a consistent increase or decrease of these factors along the intestine.
Both pteroylglutamic acid and vitamin B12 appear to be synthesized in relatively large amounts in the large intestine; in a patient with pernicious anemia, the daily output in the stools may be about 5 micrograms of vitamin B12 and 0.5 mg. of pteroylglutamic acid. Similar quantities may be present in patients not suffering from this disorder.
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Cited by
38 articles.
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