CIRCULATING ANTICOAGULANTS IN HEMOPHILIA AND IN HEMOPHILIA-LIKE DISEASE

Author:

SINGER KARL1,MOND ERNEST1,HYMAN JULIAN1,LEVY ROBERT C.1

Affiliation:

1. Department of Hematologic Research, Medical Research Institute, and the Department of Medicine, Michael Reese Hospital, Chicago, Ill.

Abstract

Abstract Hemophilia-like disease may be defined as a hemorrhagic diathesis characterized by a prolonged clotting time and the presence of a circulating anticoagulant. Clinical data, such as occurrence in females or onset late in life in males, are of great value in establishing the diagnosis. It is to be distinguished from hemophilia complicated by the development of an anticoagulant following blood transfusions. Differentiation of these disorders is of practical significance because hemophilia-like disease is not hereditary and the clotting anomaly may disappear spontaneously. 2. Two cases with circulating anticoagulants are reported. In the first patient with hemophilia-like disease the anticoagulant was dialyzable and present for a limited period of time only. In the second patient, a 4 year old boy, the distinction between hemophilia-like disease due to an anticoagulant and pre-existing hemophilia with a complicating anticoagulant could not be made. 3. Analysis of the mode of action of the anticoagulants in these 2 cases showed interference with the formation of thromboplastin, although some antithromboplastic activity could not be excluded. 4. A simple technic for testing for circulating anticoagulants is described. It is recommended that this test be performed routinely in all patients with a bleeding tendency and a prolonged clotting time.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Cited by 43 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Critical Review of Contemporary Cellulartherapy (Celltherapy);Journal of Gerontology;1970-04-01

2. BIBLIOGRAPHY;Blood Platelets in Man and Animals;1969

3. Haemorrhagic diathesis in children associated with vitamin K deficiency;Journal of Clinical Pathology;1967-05-01

4. A CASE OF EQUINE HAEMOPHILIA;Australian Veterinary Journal;1967-03

5. “Inhibitor Like” Effects of Hematoporphyrin on Factor VIII (Antihaemophilic Globulin);Thrombosis and Haemostasis;1967

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