Targeted disruption of the murine tissue factor gene results in embryonic lethality

Author:

Toomey JR1,Kratzer KE1,Lasky NM1,Stanton JJ1,Broze GJ Jr1

Affiliation:

1. Division of Hematology, Washington University School of Medicine, Barnes-Jewish Hospital, St Louis MO, USA.

Abstract

Abstract Tissue factor (TF) is an integral membrane glycoprotein that is believed to be the physiologic initiator of the blood coagulation cascade. Disruption of the mouse tissue factor gene leads to embryonic lethality between days E9.5-E11.5 of gestation. On E9.5, TF(-/-) embryos appear indistinguishable from their TF(+/+) and TF(+/-) littermates. By E10.5, TF(-/-) embryos are severely growth retarded, appear nearly bloodless, and are in most cases dead. Initial observations suggest that TF(-/-) embryos are dying of circulatory failure. Approximately 15% of the TF(-/-) embryos survive beyond E10.5, but none complete gestation. Heterozygotes appear normal and free of bleeding complications.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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