Studies on Platelets

Author:

ADELSON EDWARD1,STEFANINI MARIO1

Affiliation:

1. Ziskind Laboratories (Hematology Section) of the Joseph H. Pratt and New England Center Hospitals, and the Department of Medicine, Tufts College Medical School, Boston, Mass. This work was completed under contract AT(30-1) 1276 between the Atomic Energy Commission and the New England Center Hospital.

Abstract

Abstract 1. The serum of a patient with thrombotic thrombocytopenic purpura was found to contain an agglutinin active against sheep red cells and heterologous platelets (dog, rabbit and rat), but not against human platelets. The activity of the agglutinin was not affected by absorption with gels, treatment with ion-exchange resins, filtration through Seitz filters or heating of the serum at 56 C. The antibody was found to be present in the salt soluble fraction of the serum proteins. The agglutinin could not be eluted from the agglutinated platelets, was absorbed completely by guinea pig kidney and incompletely by beef erythrocyte antigen (Forssman’s variety). 2. Ability to agglutinate heterologous platelets was found to be a property of sera exhibiting a high titer of heterophil antibodies of the Forssman or non-Forssman variety. 3. It is not likely that the presence of such heterophil agglutinin was of importance in the pathogenesis of the hemolytic anemia and thrombocytopenia of the patient; rather, it could be an effect of the active lytic process of red cells and platelets. Whether the finding had diagnostic significance in the ill-defined syndrome of thrombotic thrombocytopenic purpura remains to be established with the observation of further cases.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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1. Immunological Granulocytopenia and Agranulocytosis: Clinical Aspects;Acta Medica Scandinavica;2009-04-24

2. LITERATURVERZEICHNIS;Acta Medica Scandinavica;2009-04-24

3. Studies on Blood Coagulation Factors in a Case of Liver Cirrhosis;Acta Medica Scandinavica;2009-04-24

4. Thrombotic Thrombocytopenic Purpura with Autoimmune Pancytopenia;Acta Haematologica;1974

5. Diffuse Intravascular Coagulation: An Analysis of a Basic Mechanism of Disease;CRC Critical Reviews in Clinical Laboratory Sciences;1972-01

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