An Arg/Ser Substitution in the Second Epidermal Growth Factor–Like Module of Factor IX Introduces an O-Linked Carbohydrate and Markedly Impairs Activation by Factor XIa and Factor VIIa/Tissue Factor and Catalytic Efficiency of Factor IXa
Author:
Affiliation:
1. From the Department of Haematology, Westmead Hospital and University of Sydney, Sydney, New South Wales; and the Centre for Thrombosis and Vascular Research, School of Pathology, University of New South Wales, Sydney, Australia.
Abstract
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Link
http://ashpublications.org/blood/article-pdf/94/1/156/1655100/156.pdf
Reference41 articles.
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2. Activation of factor IX by the reaction product of tissue factor and factor VII: Additional pathway for initiating blood coagulation.;Osterud;Proc Natl Acad Sci USA,1977
3. Cofactor proteins in the assembly and expression of blood clotting enzyme complexes.;Mann;Ann Rev Biochem,1988
4. The molecular basis of blood coagulation.;Furie;Cell,1988
5. Isolation and characterization of a cDNA coding for a human factor IX.;Kurachi;Proc Natl Acad Sci USA,1982
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