The Plasmacytoma Resistance Gene, Pctr2, Delays the Onset of Tumorigenesis and Resides in the Telomeric Region of Chromosome 4

Author:

Mock Beverly A.1,Hartley Janet1,Le Tissier Paul1,Wax Judith S.1,Potter Michael1

Affiliation:

1. From the Laboratory of Genetics, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD; the Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD; the Division of Virology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK; and PerImmune, Inc, Rockville, MD.

Abstract

AbstractMouse plasmacytomas share pathogenetic features in common with both multiple myeloma and Burkitt's lymphoma in humans. Susceptibility to plasmacytoma induction by intraperitoneal pristane in mice is controlled by multiple genes. At least two of these genes reside on mouse chromosome 4 in regions of the genome sharing linkage homology with human chromosomes 9p21, 1p32, and 1p36. A series of congenic strains recombinant for regions of mouse chromosome 4 in the vicinity of the Pctr2 predisposition locus were created and typed for their tumor susceptibility/resistance phenotypes. These strains were derived by introgressively backcrossing alleles from resistant DBA/2 mice onto the susceptible BALB/cAnPt background. Six resistant and two susceptible strains were allelotyped for 10 genes and 49 random DNA markers to identify the smallest region of overlap in the resistant strains. These studies have determined that the Pctr2 locus resides in either a 500-kb interval proximal to Nppa, or in a 1- to 2-centiMorgan (cM) interval distal to Nppa. In these congenic strain analyses, the Nppa and Fv1 loci, in addition to genes within about 1 cM of these loci, have been excluded as candidates for the Pctr2 locus. A relevant locus that may reside in this interval is Rep2; it is associated with the efficiency of repairing X-ray induced DNA damage sustained during the G2 phase of the mitotic cycle. The Pctr2 locus acts in a codominant fashion. F1 hybrids between resistant and susceptible congenic strains exhibit a reduced tumor incidence and a significant delay in the onset of tumorigenesis. Identification and eventual cloning of the Pctr2 locus may assist in the identification of genes involved in many types of cancer showing aberrations in human chromosome 1p36.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference30 articles.

1. Immunoglobulin-producing tumors and myeloma proteins of mice.;Potter;Physiol Rev,1972

2. Plasmacytomagenesis in mice: Model of neoplastic development dependent upon chromosomal translocations.;Potter;Carcinogenesis,1992

3. Activation of cellular oncogenes in hemopoietic cells by chromosomal translocation.;Cory;Adv Cancer Res,1986

4. Activated neutrophils induce prolonged DNA damage in neighboring cells.;Shacter;Carcinogenesis,1988

5. Susceptibility and resistance to plasmacytomagenesis: Possible role of genes that modify efficiency of chromatin repair.;Potter;Curr Top Microbiol Immunol,1988

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3