Characterization of Maternal Isoagglutinins in ABO Hemolytic Disease of the Newborn

Author:

FONG SUSIE W.12,NUCKTON ARLENE13,FUDENBERG H. H.14

Affiliation:

1. Departments of Pediatrics and Medicine, University of California School of Medicine, San Francisco, Calif.

2. U. S. P. H. S. (1961-1963); Clinical Instructor, Department of Pediatrics, University of California School of Medicine, San Francisco, Calif.

3. Department of Pediatrics, University of California School of Medicine, San Francisco, Calif.

4. Hematology Unit, Department of Medicine, University of California School of Medicine, San Francisco, Calif. Associate Professor of Immunology, University of California, Berkeley, Calif.

Abstract

Abstract Sera of group O mothers of infants with and without ABO hemolytic disease of the newborn were fractionated by diethylaminoethyl-cellulose chromatography and density gradient ultracentrifugation. Whole sera and serum fractions were evaluated for activity by various test systems currently used for the antenatal prediction of ABO hemolytic disease of the newborn. The results of these studies did not show any single serologic property that would unequivocally diflerentiate between the isoantibodies of mothers of affected infants and mothers of normal infants of incompatible blood group.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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