A Quantitative Immunogenetic Study of Gene Suppression Involving A1 and H Antigens of the Erythrocyte without Affecting Secreted Blood Group Substances. The ABH Phenotypes Ahm and Ohm-Reference-Cited by-同舟云学术

A Quantitative Immunogenetic Study of Gene Suppression Involving A1 and H Antigens of the Erythrocyte without Affecting Secreted Blood Group Substances. The ABH Phenotypes Ahm and Ohm

Published:1965-04-01 Issue:4 Volume:25 Page:470-485
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

SOLOMON JOEL M.¹²,WAGGONER ROBERT³⁴,LEYSHON WEBSTER C.⁵⁶

Affiliation:

1. National Research Laboratory, Western Division, Los Angeles, California.

2. The American National Red Cross, National Research Laboratory, Western Division, Los Angeles, California. Present address: Training Director, Blood Program, The American National Red Cross, National Headquarters, Washington, D. C.

3. National Research Laboratory, Washington, D. C.

4. Technical Services Section, The American National Red Cross, National Research Laboratory, Washington, D. C. Present address: Chief Technologist, The American National Red Cross, Appalachian Regional Blood Center, Roanoke, Va.

5. National Institutes of Health, National Institute of Dental Research, Bethesda, Md.

6. Medical Investigations Branch, National Institutes of Health, National Institute of Dental Research, Bethesda, Md.

Abstract

Abstract The Ahm phenotype is distinguished by the absence of H from the cells and anti-H from the serum, the presence of Ax antigen on the cells and A1 and H antigens in the secretions. Similarly, Ohm has no cellular H or serum anti-H and normal quantities of H substances are found in the saliva. Both phenotypes appear to result from the action of a recessive gene, possibly sex-linked, suppressing H and A1 on the cells but with no effect on the Ax antigen. Ax is considered to be largely independent of the biosynthetic pathway that proposes H substance as a precursor to A and B antigens. Quantitative hemagglutination studies also disclosed evidence of other genes modifying the quantitative expression of cellular A and H.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/25/4/470/754266/470.pdf

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