Relation of Reticulocytosis to Positive Coombs Tests in NZB and Other Mice-Reference-Cited by-同舟云学术

Relation of Reticulocytosis to Positive Coombs Tests in NZB and Other Mice

Published:1965-12-01 Issue:6 Volume:26 Page:790-797
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

GILTINAN PAMELA J.¹,NORINS LESLIE C.¹,HOLMES MARGARET C.¹²

Affiliation:

1. Walter & Eliza Hall Institute of Medical Research, Melbourne, Australia.

2. Present address: United States Public Health Service, Venereal Disease Research Laboratories, Communicable Disease Center, Atlanta, Ga.

Abstract

Abstract The presence of a reticulocytosis was found to be irrelevant to the development of a positive Coombs test when an appropriate anti-globulin reagent is used. When a serum made against mouse-whole serum is used, any circumstance leading to the firm attachment of serum proteins to erythrocytes will lead to agglutination. Blood containing moderate to high reticulocyte levels (20-86.5 per cent) gave a proportion of "false-positive" Coombs tests, especially blood from strains HI and C57/B1, but no anti-globulin Coombs reactions were obtained. Immunoelectrophoretic tests showed that 3 lines in the β globulin area, one of which was probably transferrin, were removed by absorption with reticulocytes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/26/6/790/572283/790.pdf

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Surface membrane proteins and glycoproteins of red blood cells from normal and anaemic mice;Comparative Biochemistry and Physiology Part B: Comparative Biochemistry;1982-01

2. Mechanisms of anemia in Aleutian disease viral infection of mink;Veterinary Microbiology;1979-08

3. IMMUNOGLOBULINS IN NZB/BL MICE;Journal of Experimental Medicine;1968-01-01

4. The Direct Coombs' Test: Its Clinical Significance;Annals of Internal Medicine;1968-01-01

5. The Immunology and Pathology of NZB Mice;Advances in Immunology Volume 9;1968