Evaluation of Nialamide on the Coagulation of Blood-Reference-Cited by-同舟云学术

Evaluation of Nialamide on the Coagulation of Blood

Published:1964-09-01 Issue:3 Volume:24 Page:289-298
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

MASCHOUF CHAPOUR¹²,ROBINSON ROGER W.¹³,LEBEAU RAOUL J.¹⁴

Affiliation:

1. Medical Division and the Research Laboratory, The Memorial Hospital, Worcester, Massachusetts.

2. Teheran, iran, Exchange Visitor in the United States and Assistant Resident in Medicine, Memorial Hospital, Worcester, Mass.

3. Department of Internal Medicine and Director of the Research Laboratory, Memorial Horpital, Worcester, Mass.

4. the Research Laboratory, Memorial Hospital, Worcester, Mass.

Abstract

Abstract Nialamide at a single oral dose of about 3 mg./Kg. body weight produced decreased prothrombin activation by rendering the platelets less effective. It also decreased the adhesiveness of the platelets as measured by two different technics. A new technic for measuring the adhesiveness of the platelets has been described. It utilized a principle by which venous blood directly circulated through a column of fine glass beads, after which the platelets were reduced in number.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/24/3/289/571759/289.pdf

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2. REFERENCES;Acta Medica Scandinavica;2009-04-24

3. Test of Platelet Function;Vox Sanguinis;1981-01

4. Effects of Prostaglandins on Platelet Function;The Prostaglandins;1972

5. Trends in the development of antithrombotic agents;The American Journal of Cardiology;1971-06