A European collaborative study of cyclophosphamide, bortezomib, and dexamethasone in upfront treatment of systemic AL amyloidosis

Author:

Palladini Giovanni1,Sachchithanantham Sajitha2,Milani Paolo1,Gillmore Julian2,Foli Andrea1,Lachmann Helen2,Basset Marco1,Hawkins Philip2,Merlini Giampaolo1,Wechalekar Ashutosh D.2

Affiliation:

1. Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, and Department of Molecular Medicine, University of Pavia, Pavia, Italy; and

2. National Amyloidosis Centre, University College London Medical School, Royal Free Hospital Campus, London, United Kingdom

Abstract

Key Points CyBorD achieves excellent outcome in noncardiac patients with AL amyloidosis and can rescue subjects with reversible heart damage. The outcome of high-risk patients remains poor, but response to CyBorD can also improve survival in this group.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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