Myelogenous Leukemia in the Rat

Author:

MOLONEY WILLIAM C.12,DORR ANDREW D.13,DOWD GERALDINE14,BOSCHETTI ANTONIO E.15

Affiliation:

1. Research Laboratory, Holy Ghost Hospital, Cambridge, Mass., and the Hematology Laboratory (Tufts), Boston City Hospital, and the Department of Medicine, Tufts University Medical School, Boston.

2. Hematology Laboratory (Tufts), Boston City Hospital, and Clinical Professor of Medicine, Tufts University Sahool of Medicine, Boston, Mass.

3. National Cancer Institute, National Institute of Health, Bethesda, Md.

4. Research Laboratory, Holy Ghost Hospital, Cambridge, Mass.

5. Department of Research Pathology, Holy Ghost Hospital, Cambridge, Mass., and Senior instructor of Pathology, Tufts University School of Medicine, Boston, Mass.

Abstract

Abstract Observations on growth and other characteristics of subcutaneously transplanted chloroleukemia in non-inbred rats have been described in this report. This chloroleukemia cytologically is an acute or subacute, not chronic, myelogenous leukemia. Because of serious immunologic differences, the experimental usefulness of subtransferred chloroleukemia is greatly limited. However, myelogenous leukemia in the rat, induced by chemical agents or ionizing radiation, may offer a valuable approach to the study of leukemogenic mechanisms.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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