The Effect of "Minute" and "Titrated" Amounts of Folic Acid on the Megaloblastic Anemia of Tropical Sprue-Reference-Cited by-同舟云学术

The Effect of "Minute" and "Titrated" Amounts of Folic Acid on the Megaloblastic Anemia of Tropical Sprue

Published:1961-12-01 Issue:6 Volume:18 Page:623-636
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

SHEEHY T. W.¹²,RUBINI M. E.¹³,PEREZ-SANTIAGO E.¹⁴,SANTINI R.¹⁵,HADDOCK J.¹⁴

Affiliation:

1. U. S. Army Tropical Research Medical Center and the Department of Medicine, University of Puerto Rico.

2. U. S. Army Tropical Research Medical Laboratory, APO 851, New York, N. Y.

3. Present address: Department of Metabolism, Wadsworth V. A. Hospital, Los Angeles, Calif.

4. Dept. of Medicine, University of Puerto Rico School of Medicine.

5. U. S. Army Tropical Research Medical Laboratory.

Abstract

Abstract A therapeutic trial with "minute" and "titrated" doses of folic acid was performed in 30 patients with the megaloblastic anemia of tropical sprue. Eleven patients responded hematologically to 25 µg. daily doses of the vitamin; nine patients responded to "titrated" doses ranging from 75 to 250 µg. daily. Eleven patients failed to respond to either "minute" or "titrated" doses of the vitamin. The implications and possible reasons for the success or failure of microdoses of folic acid in sprue were discussed.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/18/6/623/751742/623.pdf

Cited by 69 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Fallacies of clinical studies on folic acid hazards in subjects with a low vitamin B12 status;Critical Reviews in Toxicology;2020-02-07

2. Ordering folate assays is no longer justified for investigation of anemias, in folic acid fortified countries;BMC Research Notes;2010-01-25

3. Metabolic Effects and Diagnostic Value of Small Doses of Folic Acid and B12 in Megaloblastic Anemias1;Acta Medica Scandinavica;2009-04-24

4. CHAPTER 11: Summary to Section II;Scandinavian Journal of Haematology;2009-04-24

5. 11 Neurological complications of acquired cobalamin deficiency: clinical aspects;Baillière's Clinical Haematology;1995-09