Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8;21) AML cells-Reference-Cited by-同舟云学术

Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8;21) AML cells

Published:2013-10-03 Issue:14 Volume:122 Page:2467-2476
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Torgersen Maria Lyngaas¹,Engedal Nikolai²,Bøe Stig-Ove³,Hokland Peter⁴,Simonsen Anne¹

Affiliation:

1. Department of Biochemistry, Institute of Basic Medical Sciences, Faculty of Medicine, and

2. Centre for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, University of Oslo, Oslo, Norway;

3. Department of Medical Biochemistry, Institute of Clinical Biochemistry, Oslo University Hospital, Rikshospitalet, Oslo, Norway; and

4. Department of Hematology, Aarhus University Hospital, Aarhus, Denmark

Abstract

Key Points In AML1-ETO–positive AML cells, HDAC inhibitors induce autophagy, which acts as a prosurvival signal to limit HDAC-induced cell death. In contrast to the fusion oncoproteins PML-RARA and breakpoint cluster region–abelson, AML1-ETO is not degraded by either basal- or drug-induced autophagy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/14/2467/1370694/2467.pdf

Reference47 articles.

1. Mammalian autophagy: core molecular machinery and signaling regulation.;Yang;Curr Opin Cell Biol,2010

2. Targeting autophagy during cancer therapy to improve clinical outcomes.;Levy;Pharmacol Ther,2011

3. Deconvoluting the context-dependent role for autophagy in cancer.;White;Nat Rev Cancer,2012

4. Autophagy is a therapeutic target in anticancer drug resistance.;Chen;Biochim Biophys Acta,2010

5. Principles and current strategies for targeting autophagy for cancer treatment.;Amaravadi;Clin Cancer Res,2011

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