Genome-wide copy-number analyses reveal genomic abnormalities involved in transformation of follicular lymphoma

Author:

Bouska Alyssa1,McKeithan Timothy W.1,Deffenbacher Karen E.1,Lachel Cynthia1,Wright George W.2,Iqbal Javeed1,Smith Lynette M.3,Zhang Weiwei1,Kucuk Can1,Rinaldi Andrea4,Bertoni Francesco45,Fitzgibbon Jude6,Fu Kai1,Weisenburger Dennis D.7,Greiner Timothy C.1,Dave Bhavana J.8,Gascoyne Randy D.9,Rosenwald Andreas10,Ott German11,Campo Elias12,Rimsza Lisa M.13,Delabie Jan14,Jaffe Elaine S.15,Braziel Rita M.16,Connors Joseph M.17,Staudt Louis M.18,Chan Wing-Chung1

Affiliation:

1. Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE;

2. Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD;

3. College of Public Health Biostatistics, University of Nebraska Medical Center, Omaha, NE;

4. Lymphoma and Genomics Research Program, Institute of Oncology Research, Bellinzona, Switzerland;

5. Lymphoma Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland;

6. Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom;

7. Department of Pathology, City of Hope National Medical Center, Duarte, CA;

8. Center for Human Genetics, University of Nebraska Medical Center, Omaha, NE;

9. Center for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada;

10. Pathology, University of Würzburg, Würzburg, Germany;

11. Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany;

12. Hematopathology Unit, Hospital Clinic, Barcelona, Spain;

13. Department of Pathology, University of Arizona, Tucson, AZ;

14. Department of Pathology, University of Toronto, Toronto, ON, Canada;

15. Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD;

16. Oregon Health Sciences Center, Portland, OR;

17. Division of Medical Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada; and

18. Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD

Abstract

Key Points Chromosome copy-number alterations that may affect immune surveillance and the NF-κB and p53 pathways are more frequent in tFL than FL. Abnormalities involving chromosomes 6 and X are predictive of overall survival in FL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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