C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation-Reference-Cited by-同舟云学术

C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation

Published:2013-11-14 Issue:20 Volume:122 Page:3473-3481
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Asgari Elham¹,Le Friec Gaelle¹,Yamamoto Hidekazu¹,Perucha Esperanza²,Sacks Steven S.¹,Köhl Jörg³⁴,Cook H. Terence⁵,Kemper Claudia¹

Affiliation:

1. Division of Transplantation Immunology and Mucosal Biology, MRC Centre for Transplantation, King’s College London, Guy’s Hospital, London, United Kingdom;

2. Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection and Inflammatory Diseases, King’s College School of Medicine, London, United Kingdom;

3. Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany;

4. Division of Cellular and Molecular Immunology, Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH; and

5. Centre for Complement and Inflammation Research, Department of Medicine, Imperial College, London, United Kingdom

Abstract

Key Points C3aR activation increases ATP efflux, NLRP3 inflammasome activation, and IL-1β secretion in human monocytes. C3aR-activated monocytes drive Th17 responses in vitro and likely in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/20/3473/1371544/3473.pdf

Reference57 articles.

1. Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist.;Hoffman;Lancet,2004

2. The IL-1 family: regulators of immunity.;Sims;Nat Rev Immunol,2010

3. IL-1beta processing in host defense: beyond the inflammasomes.;Netea;PLoS Pathog,2010

4. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells.;Acosta-Rodriguez;Nat Immunol,2007

5. Th17 cells in inflammation.;Kimura;Int Immunopharmacol,2011

Cited by 262 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Role of inflammation in diabetic macular edema and neovascular age-related macular degeneration;Survey of Ophthalmology;2024-11

2. Complement 3a induces the synapse loss via C3aR in mitochondria-dependent NLRP3 activating mechanisms during the development and progression of Alzheimer’s disease;Neuroscience & Biobehavioral Reviews;2024-10

3. Decreased sialylation elicits complement‐related microglia response and bipolar cell loss in the mouse retina;Glia;2024-09-03

4. Cyclic guanosine monophosphate-adenosine monophosphate synthetase/stimulator of interferon genes signaling aggravated corneal allograft rejection through neutrophil extracellular traps;American Journal of Transplantation;2024-09

5. Local complement activation and modulation in mucosal immunity;Mucosal Immunology;2024-08